St. Louis is the largest city in the U.S. state of Missouri. The city was left in ruins in the aftermath of the Chimeran War, although the structure of the city's Gateway Arch is left nearly intact. The human resistance group called the Remnants operated from St. Louis.
Joseph Capelli and Fyodor Malikov traveled to St. Louis where they met the Remnants, where they are bargained into helping the latter in stealing a Chimeran power core as a fuel source for the Remnants' U/AV-17 Hawk.
- The presence of the Gateway Arch, as depicted in Resistance 3, is an anachronism as in real life it was constructed in 1963 and completed in 1965. Although plans and designs were made during the 1950s, due to the series' altered timeline the Arch could have been constructed and completed earlier than in reality.
- The city appears in both the teaser trailer and leaked concept arts for Resistance 3.
- The Chimera appear to have attacked St. Louis and the surrounding areas around Christmas, as decorations can be seen throughout Wrightsburg and a Christmas tree can be found in a abandoned apartment building during City of the Past.