In Assimilation one player starts out as a Cloven, the other seven are Maquis. The Cloven player has to hunt down the remaining Maquis. The Maquis cannot permanently kill the cloven. Any Maquis killed by the Cloven become Cloven when they respawn. The Maquis's objective is to survive within a time limit, and they win if at least one Maquis survives. The Cloven's objective is to kill all Maquis within a time limit, and they win if they do so. This game mode was only featured in Resistance: Retribution.

Resistance Multiplayer Game Modes
Resistance: Fall of Man Deathmatch | Team Deathmatch | Capture the Flag | Meltdown | Assault | Breach | Skirmish
Resistance 2 Deathmatch | Team Deathmatch | Core Control | Meltdown | Skirmish
Resistance: Retribution Deathmatch | Team Deathmatch | Containment | Capture the Flag | Assimilation
Resistance 3 Team Deathmatch | Chain Reaction | Deathmatch | Breach | Capture the Flag | War Games | Invasion
Resistance: Burning Skies Deathmatch | Team Deathmatch | Survival